Synthesis of silver-cobalt nanoparticles by chemical reduction method and its effects on serum levels of thyroid hormones in adult male rats

ABSTRACTObjective(s): Silver-cobalt nanoparticles have anti-fungal properties and are used in medicine. In the present study, the effect of silver-cobalt nanoparticles on serum levels of T3 and T4 hormones was investigated. Silver-cobalt nanoparticles were synthesized by chemical reduction.Methods: In this experimental study, 28 male adult Wistar rats (approximately 180-220 gr) were used. Animals were divided into 4 groups of 7. The control group did not receive any medication. Experimental groups 1 and 2 received silver-cobalt nanoparticles, which were synthesized during 75 seconds, received doses of 25 and 100 mg / kg intraperitoneally for 14 days, respectively. The experimental group 3 received silver-cobalt nanoparticles that were synthesized during 300 seconds at a doses of 25 mg / kg intraperitoneally for 14 days. At the end of the trial, blood sampling was performed to measure hormones. The mean serum levels of T3 and T4 hormones were analyzed by appropriate statistical tests including ANOVA and Duncan test.Results: Serum levels of T4 in experimental groups 2 and 3 showed a significant decrease compared to control group. Serum T3 level did not change significantly in all experimental groups compared to control group (p